Propargyl-PEG4-(CH2)3-acid

Product Name: Propargyl-PEG4-(CH2)3-acid
CAS No.: 1872433-74-3
Chemical Name: Propargyl-PEG4-(CH2)3-acid
Synonyms: Propargyl-PEG4-CH2-acid;5,8,11,14-Tetraoxaheptadec-16-ynoic acid;4,7,10,13-tetraoxaheptadec-1-yn-17-oic acid
CBNumber: CB43363993
Molecular Formula: C13H22O6
Formula Weight: 274.31
MOL File: 1872433-74-3.mol

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Propargyl-PEG4-(CH2)3-acid Property

Boiling point:: 401.0±40.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
pka: 4.63±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23117
Product name: Propargyl-PEG4-(CH2)3-acid
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

BroadPharm

Product number: BP-23117
Product name: Propargyl-PEG4-(CH2)3-acid
Purity: 98%
Packaging: 500mg
Price: $780
Updated: 2021/12/16

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Propargyl-PEG4-(CH2)3-acid Chemical Properties,Usage,Production

Description

Propargyl-PEG4-(CH2)3-CO2H is a linker containing a propargyl group at one end and a carboxylic acid at the other end. The carboxylic acid reacts with amine groups in the presence of activators (EDC or HATU). Under the catalyzation of copper, the propargyl group forms linkage with azide group of biomolecules.

Uses

Propargyl-PEG4-CH2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Propargyl-PEG4-(CH2)3-acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG4-(CH2)3-acid Suppliers

China 13 United States 3 Global 16

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Combi-Blocks Inc.

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Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
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1872433-74-3, Propargyl-PEG4-(CH2)3-acidRelated Search:

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Propargyl-PEG4-CH2-acid

5,8,11,14-Tetraoxaheptadec-16-ynoic acid

4,7,10,13-tetraoxaheptadec-1-yn-17-oic acid

1872433-74-3